4AYO: Structure Of The Gh47 Processing Alpha-1,2-mannosidase From Caulobacter Strain K31

Citation:
Abstract
Mannosides in the southern hemisphere: Conformational analysis of enzymatic mannoside hydrolysis informs strategies for enzyme inhibition and inspires solutions to mannoside synthesis. Atomic resolution structures along the reaction coordinate of an inverting alpha-mannosidase show how the enzyme distorts the substrate and transition state. QM/MM calculations reveal how the free energy landscape of isolated alpha-D-mannose is molded on enzyme to only allow one conformationally accessible reaction coordinate.
PDB ID: 4AYODownload
MMDB ID: 107144
PDB Deposition Date: 2012/6/21
Updated in MMDB: 2015/03
Experimental Method:
x-ray diffraction
Resolution: 0.85  Å
Source Organism:
Similar Structures:
Biological Unit for 4AYO: monomeric; determined by software (PISA)
Molecular Components in 4AYO
Label Count Molecule
Protein (1 molecule)
1
Mannosyl-oligosaccharide 1,2-alpha-mannosidase
Molecule annotation
Chemicals (4 molecules)
1
2
2
1
3
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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