National Center for
4AYO: Structure Of The Gh47 Processing Alpha-1,2-mannosidase From Caulobacter Strain K31
The reaction coordinate of a bacterial GH47 alpha-mannosidase: a combined quantum mechanical and structural approach
Angew. Chem. Int. Ed. Engl. (2012) 51 p.10997-11001
Mannosides in the southern hemisphere: Conformational analysis of enzymatic mannoside hydrolysis informs strategies for enzyme inhibition and inspires solutions to mannoside synthesis. Atomic resolution structures along the reaction coordinate of an inverting alpha-mannosidase show how the enzyme distorts the substrate and transition state. QM/MM calculations reveal how the free energy landscape of isolated alpha-D-mannose is molded on enzyme to only allow one conformationally accessible reaction coordinate.
* Click molecule labels to explore molecular sequence information.