4AS4: Structure Of Human Inositol Monophosphatase 1

Citation:
Abstract
Inositol monophosphatase (IMPase) catalyses the hydrolysis of inositol monophosphate to inositol and is crucial in the phosphatidylinositol (PI) signalling pathway. Lithium, which is the drug of choice for bipolar disorder, inhibits IMPase at therapeutically relevant plasma concentrations. Both mouse IMPase 1 (MmIMPase 1) and human IMPase 1 (HsIMPase 1) were cloned into pRSET5a, expressed in Escherichia coli, purified and crystallized using the sitting-drop method. The structures were solved at resolutions of 2.4 and 1.7 A, respectively. Comparison of MmIMPase 1 and HsIMPase 1 revealed a core r.m.s. deviation of 0.516 A.
PDB ID: 4AS4Download
MMDB ID: 103752
PDB Deposition Date: 2012/4/27
Updated in MMDB: 2012/10
Experimental Method:
x-ray diffraction
Resolution: 1.7  Å
Source Organism:
Similar Structures:
Biological Unit for 4AS4: dimeric; determined by author and by software (PISA)
Molecular Components in 4AS4
Label Count Molecule
Proteins (2 molecules)
2
Inositol Monophosphatase 1(Gene symbol: IMPA1)
Molecule annotation
Chemicals (15 molecules)
1
2
2
6
3
7
* Click molecule labels to explore molecular sequence information.

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