4AEL: Pde10a In Complex With The Inhibitor Az5

Citation:
Abstract
A series of 1,6-naphthyridine-based compounds was synthesized as potent phosphodiesterase 10A (PDE10A) inhibitors. Structure-based chemical modifications of the discovered chemotype served to further improve potency and selectivity over DHODH, laying the foundation for future optimization efforts.
PDB ID: 4AELDownload
MMDB ID: 96839
PDB Deposition Date: 2012/1/11
Updated in MMDB: 2012/08
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 4AEL: monomeric; determined by author and by software (PISA)
Molecular Components in 4AEL
Label Count Molecule
Protein (1 molecule)
1
Camp and Camp-inhibited Cgmp 3', 5'-cyclic Phosphodiesterase 10A(Gene symbol: PDE10A)
Molecule annotation
Chemicals (3 molecules)
1
1
2
1
3
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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