National Center for
4AEL: Pde10a In Complex With The Inhibitor Az5
Bioorg. Med. Chem. Lett. (2012) 22 p.1944-1948
A series of 1,6-naphthyridine-based compounds was synthesized as potent phosphodiesterase 10A (PDE10A) inhibitors. Structure-based chemical modifications of the discovered chemotype served to further improve potency and selectivity over DHODH, laying the foundation for future optimization efforts.