3ZXY: Structure Of S218a Mutant Of The Protease Domain Of Pata

Cyanobactins, including patellamides, are a group of cyanobacterial post-translationally modified ribosomal cyclic peptides. The final product should in theory be predictable from the sequence of the precursor peptide and the associated tailoring enzymes. Understanding the mechanism and recognition requirements of these enzymes will allow their rational engineering. We have identified three new cyanobactins from a Cyanothece PCC 7425 culture subjected to a heat shock. One of these compounds revealed a novel signature signal for ThcA, the subtilisin-like serine protease that is homologous to the patellamide protease PatA. The crystal structure of the latter and modelling studies allow rationalisation of the recognition determinants for both enzymes, consistent with the ribosomal biosynthetic origin of the new compounds.
PDB ID: 3ZXYDownload
MMDB ID: 102385
PDB Deposition Date: 2011/8/16
Updated in MMDB: 2012/12
Experimental Method:
x-ray diffraction
Resolution: 1.58  Å
Source Organism:
Similar Structures:
Biological Unit for 3ZXY: monomeric; determined by author and by software (PISA)
Molecular Components in 3ZXY
Label Count Molecule
Protein (1 molecule)
Subtilisin-like Protein
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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