3ZPK: Atomic-resolution structure of a quadruplet cross-beta amyloid fibril

Citation:
Abstract
The cross-beta amyloid form of peptides and proteins represents an archetypal and widely accessible structure consisting of ordered arrays of beta-sheet filaments. These complex aggregates have remarkable chemical and physical properties, and the conversion of normally soluble functional forms of proteins into amyloid structures is linked to many debilitating human diseases, including several common forms of age-related dementia. Despite their importance, however, cross-beta amyloid fibrils have proved to be recalcitrant to detailed structural analysis. By combining structural constraints from a series of experimental techniques spanning five orders of magnitude in length scale--including magic angle spinning nuclear magnetic resonance spectroscopy, X-ray fiber diffraction, cryoelectron microscopy, scanning transmission electron microscopy, and atomic force microscopy--we report the atomic-resolution (0.5 A) structures of three amyloid polymorphs formed by an 11-residue peptide. These structures reveal the details of the packing interactions by which the constituent beta-strands are assembled hierarchically into protofilaments, filaments, and mature fibrils.
PDB ID: 3ZPKDownload
MMDB ID: 115598
PDB Deposition Date: 2013/2/28
Updated in MMDB: 2013/12
Experimental Method:
solid-state nmr; electron microscopy
Similar Structures:
Biological Unit for 3ZPK: 1824-meric
Molecular Components in 3ZPK
Label Count Molecule
Proteins (1824 molecules)
1824
Transthyretin(Gene symbol: Ttr)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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