3WLF: Crystal structure of (R)-carbonyl reductase from Candida Parapsilosis in complex with (R)-1-phenyl-1,2-ethanediol

Citation:
Abstract
Structure-guided design of substrate-binding pocket inversed the stereoselectivity of an NADH-dependent medium-chain alcohol dehydrogenase (MDR) from Prelog to anti-Prelog. The pocket-forming amino acids, especially the unconserved residues as hotspots, play critical roles in directing MDRs' stereoselectivity.
PDB ID: 3WLFDownload
MMDB ID: 121436
PDB Deposition Date: 2013/11/9
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 3WLF: tetrameric; determined by author and by software (PISA)
Molecular Components in 3WLF
Label Count Molecule
Proteins (4 molecules)
4
(R)-specific Carbonyl Reductase
Molecule annotation
Chemicals (12 molecules)
1
4
2
8
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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