3WBR: Crystal structure of carbohydrate recognition domain of Blood Dendritic Cell Antigen-2 (BDCA2) lectin (crystal form-3)

We report on crystal structures of a carbohydrate recognition domain (CRD) of human C-type lectin receptor blood dendritic cell antigen-2 (BDCA2). Three different crystal forms were obtained at 1.8-2.3 A resolution. In all three, the CRD has a basic C-type lectin fold, but a long loop extends away from the core domain to form a domain-swapped dimer. The structures of the dimers from the three different crystal forms superimpose well, indicating that domain swapping and dimer formation are energetically stable. The structure of the dimer is compared with other domain-swapped proteins, and a possible regulation mechanism of BDCA2 is discussed.
PDB ID: 3WBRDownload
MMDB ID: 116172
PDB Deposition Date: 2013/5/20
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 3WBR: dimeric; determined by author and by software (PISA)
Molecular Components in 3WBR
Label Count Molecule
Proteins (2 molecules)
C-type Lectin Domain Family 4 Member C(Gene symbol: CLEC4C)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB