3VRB: Mitochondrial rhodoquinol-fumarate reductase from the parasitic nematode Ascaris suum with the specific inhibitor flutolanil and substrate fumarate

Citation:
Abstract
In the anaerobic respiratory chain of the parasitic nematode Ascaris suum, complex II couples the reduction of fumarate to the oxidation of rhodoquinol, a reverse reaction catalyzed by mammalian complex II. In this study, the first structure of anaerobic complex II of mitochondria was determined. The structure, composed of four subunits and five co-factors, is similar to that of aerobic complex II, except for an extra peptide found in the smallest anchor subunit of the A. suum enzyme. We discuss herein the structure-function relationship of the enzyme and the critical role of the low redox potential of rhodoquinol in the fumarate reduction of A. suum complex II.
PDB ID: 3VRBDownload
MMDB ID: 101160
PDB Deposition Date: 2012/4/7
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 2.91  Å
Source Organism:
Similar Structures:
Biological Unit for 3VRB: tetrameric; determined by author and by software (PISA)
Molecular Components in 3VRB
Label Count Molecule
Proteins (4 molecules)
1
Flavoprotein Subunit of Complex II
Molecule annotation
1
Iron-sulfur Subunit of Succinate Dehydrogenase
Molecule annotation
1
Cytochrome B-large Subunit
Molecule annotation
1
Succinate Dehydrogenase [ubiquinone] Cytochrome B Small Subunit, Mitochondrial
Molecule annotation
Chemicals (8 molecules)
1
1
2
1
3
1
4
1
5
1
6
1
7
1
8
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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