3VQS: Crystal structure of HCV NS5B RNA polymerase with a novel piperazine inhibitor

PDB ID: 3VQSDownload
MMDB ID: 101792
PDB Deposition Date: 2012/3/30
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 3VQS: monomeric; determined by author and by software (PISA)
Molecular Components in 3VQS
Label Count Molecule
Protein (1 molecule)
1
RNA-directed RNA Polymerase
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(2R)-4-(5-cyclopropyl[1,3]thiazolo[4,5-d]pyrimidin-2-yl)-N-[3-fluoro-4-(trifluoromethoxy)benzyl]-1-{[4-(trifluoromethyl)phenyl]sulfonyl}piperazine-2-carboxamide(2R)-4-(5-cyclopropyl[1,3]thiazolo[4,5-d]pyrimidin-2-yl)-N-[3-fluoro-4-(trifluoromethoxy)benzyl]-1-{[4-(trifluoromethyl)phenyl]sulfonyl}piperazine-2-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303