3VJH: Human Ppar Gamma Ligand Binding Domain In Complex With Jkpl35

Citation:
Abstract
Human peroxisome proliferator-activated receptors (hPPARs) are ligand-dependent transcription factors that control various biological responses, and there are three subtypes: hPPARalpha, hPPARdelta, and hPPARgamma. We report here that alpha-substituted phenylpropanoic acid-type hPPAR agonists with similar structure bind to the hPPAR ligand binding domain (LBD) in different conformations, depending on the receptor subtype. These results might indicate that hPPAR ligand binding pockets have multiple binding points that can be utilized to accommodate structurally flexible hPPAR ligands.
PDB ID: 3VJHDownload
MMDB ID: 102376
PDB Deposition Date: 2011/10/20
Updated in MMDB: 2012/08
Experimental Method:
x-ray diffraction
Resolution: 2.22  Å
Source Organism:
Similar Structures:
Biological Unit for 3VJH: dimeric; determined by author and by software (PISA)
Molecular Components in 3VJH
Label Count Molecule
Proteins (2 molecules)
2
Peroxisome Proliferator-activated Receptor Gamma(Gene symbol: PPARG)
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
.