National Center for
3VE2: The 2.1 Angstrom Crystal Structure Of Transferrin Binding Protein B (Tbpb) From Serogroup B M982 Neisseria Meningitidis
Nat. Struct. Mol. Biol. (2012) 19 p.358-360
Neisseria meningitidis, the causative agent of bacterial meningitis, acquires the essential element iron from the host glycoprotein transferrin during infection through a surface transferrin receptor system composed of proteins TbpA and TbpB. Here we present the crystal structures of TbpB from N. meningitidis in its apo form and in complex with human transferrin. The structure reveals how TbpB sequesters and initiates iron release from human transferrin.