3VBO: Crystal Structure Of Formaldehyde Treated Empty Human Enterovirus 71 Particle (Cryo At 100k)

Enterovirus 71 (EV71) is a major agent of hand, foot and mouth disease in children that can cause severe central nervous system disease and death. No vaccine or antiviral therapy is available. High-resolution structural analysis of the mature virus and natural empty particles shows that the mature virus is structurally similar to other enteroviruses. In contrast, the empty particles are markedly expanded and resemble elusive enterovirus-uncoating intermediates not previously characterized in atomic detail. Hydrophobic pockets in the EV71 capsid are collapsed in this expanded particle, providing a detailed explanation of the mechanism for receptor-binding triggered virus uncoating. These structures provide a model for enterovirus uncoating in which the VP1 GH loop acts as an adaptor-sensor for cellular receptor attachment, converting heterologous inputs to a generic uncoating mechanism, highlighting new opportunities for therapeutic intervention.
PDB ID: 3VBODownload
MMDB ID: 97656
PDB Deposition Date: 2012/1/2
Updated in MMDB: 2012/05
Experimental Method:
x-ray diffraction
Resolution: 2.88  Å
Source Organism:
Similar Structures:
Biological Unit for 3VBO: 180-meric
Molecular Components in 3VBO
Label Count Molecule
Proteins (180 molecules)
Genome Polyprotein, Capsid Protein VP1
Molecule annotation
Genome Polyprotein, Capsid Protein VP2
Molecule annotation
Genome Polyprotein, Capsid Protein VP3
Molecule annotation
Chemicals (60 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB