3UKB: (R)-Cet-Bna Decamer Structure

Combining the structural elements of the second generation 2'-O-methoxyethyl (MOE) and locked nucleic acid (LNA) antisense oligonucleotide (AON) modifications yielded the highly nuclease resistant 2',4'-constrained MOE and ethyl bicyclic nucleic acids (cMOE and cEt BNA, respectively). Crystal structures of DNAs with cMOE or cEt BNA residues reveal their conformational preferences. Comparisons with MOE and LNA structures allow insights into their favourable properties for AON applications.
PDB ID: 3UKBDownload
MMDB ID: 100667
PDB Deposition Date: 2011/11/9
Updated in MMDB: 2012/08
Experimental Method:
x-ray diffraction
Resolution: 1.42  Å
Source Organism:
Biological Unit for 3UKB: dimeric; determined by author and by software (PISA)
Molecular Components in 3UKB
Label Count Molecule
Nucleotide(1 molecule)
DNA (5'-d(gpcpgptpap(rce)papcpgpc)-3')
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB