3TFL: Lytr-Cps2a-Psr Family Protein With Bound Octaprenyl Pyrophosphate Lipid

Teichoic acids and acidic capsular polysaccharides are major anionic cell wall polymers (APs) in many bacteria, with various critical cell functions, including maintenance of cell shape and structural integrity, charge and cation homeostasis, and multiple aspects of pathogenesis. We have identified the widespread LytR-Cps2A-Psr (LCP) protein family, of previously unknown function, as novel enzymes required for AP synthesis. Structural and biochemical analysis of several LCP proteins suggest that they carry out the final step of transferring APs from their lipid-linked precursor to cell wall peptidoglycan (PG). In Bacillus subtilis, LCP proteins are found in association with the MreB cytoskeleton, suggesting that MreB proteins coordinate the insertion of the major polymers, PG and AP, into the cell wall.
PDB ID: 3TFLDownload
MMDB ID: 94303
PDB Deposition Date: 2011/8/16
Updated in MMDB: 2011/10
Experimental Method:
x-ray diffraction
Resolution: 2.05  Å
Source Organism:
Similar Structures:
Biological Unit for 3TFL: monomeric; determined by software (PISA)
Molecular Components in 3TFL
Label Count Molecule
Protein (1 molecule)
Cps2a, Integral Membrane Regulatory Protein WZG
Molecule annotation
Chemicals (7 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB