3T0L: Small-molecule Inhibitors of 14-3-3 Protein-protein Interactions From Virtual Screening

Citation:
Abstract
We report first non-covalent and exclusively extracellular inhibitors of 14-3-3 protein-protein interactions identified by virtual screening. Optimization by crystal structure analysis and in vitro binding assays yielded compounds capable of disrupting the interaction of 14-3-3sigma with aminopeptidase N in a cellular assay.
PDB ID: 3T0LDownload
MMDB ID: 106133
PDB Deposition Date: 2011/7/20
Updated in MMDB: 09/2013 
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit: dimeric; determined by author, and by software (PISA)
Molecular Components
Label Count Molecule
Proteins (2 molecules)
2
14-3-3 Protein Sigma
Molecule annotation
Chemicals (16 molecules)
1
2
2
4
3
6
4
4
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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