3SWW: Crystal Structure Of Human Dpp-Iv In Complex With Sa-(+)-3- (Aminomethyl)-4-(2,4-Dichlorophenyl)-6-(2-Methoxyphenyl)- 2-Methyl- 5h-Pyrrolo[3,4-B]pyridin-7(6h)-One

Citation:
Abstract
Design, synthesis, and SAR of 7-oxopyrrolopyridine-derived DPP4 inhibitors are described. The preferred stereochemistry of these atropisomeric biaryl analogs has been identified as Sa. Compound (+)-3t, with a K(i) against DPP4, DPP8, and DPP9 of 0.37 nM, 2.2, and 5.7 muM, respectively, showed a significant improvement in insulin response after single doses of 3 and 10 mumol/kg in ob/ob mice.
PDB ID: 3SWWDownload
MMDB ID: 94636
PDB Deposition Date: 2011/7/14
Updated in MMDB: 2011/10
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 3SWW: dimeric; determined by software (PISA)
Molecular Components in 3SWW
Label Count Molecule
Proteins (2 molecules)
2
Dipeptidyl Peptidase 4(Gene symbol: DPP4)
Molecule annotation
Chemicals (16 molecules)
1
14
2
2
* Click molecule labels to explore molecular sequence information.

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