3SKG: Crystal Structure Of Beta-Site App-Cleaving Enzyme 1 (Bace-Wt) Complex With (2s)-2-((3r)-3-Acetamido-3-Isobutyl-2-Oxo-1-Pyrrolidinyl)-N- ((1s,2r)-1-(3,5-Difluorobenzyl)-2-Hydroxy-2-(1,2,3,4-Tetrahydro-3- Isoquinolinyl)ethyl)-4-Phenylbutanamide

PDB ID: 3SKGDownload
MMDB ID: 93474
PDB Deposition Date: 2011/6/22
Updated in MMDB: 2012/12
Experimental Method:
x-ray diffraction
Resolution: 2.88  Å
Source Organism:
Similar Structures:
Biological Unit for 3SKG: monomeric; determined by author and by software (PISA)
Molecular Components in 3SKG
Label Count Molecule
Protein (1 molecule)
1
Beta-secretase 1
(Gene symbol: BACE1)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(2s)-2-[(3r)-3-(Acetylamino)-3-(2-Methylpropyl)-2-Oxopyrrolidin-1-Yl]-N-{(1r,2s)-3-(3,5-Difluorophenyl)-1-Hydroxy-1-[(3r)-1,2,3,4-Tetrahydroisoquinolin-3-Yl]propan-2-Yl}-4-Phenylbutanamide(2s)-2-[(3r)-3-(Acetylamino)-3-(2-Methylpropyl)-2-Oxopyrrolidin-1-Yl]-N-{(1r,2s)-3-(3,5-Difluorophenyl)-1-Hydroxy-1-[(3r)-1,2,3,4-Tetrahydroisoquinolin-3-Yl]propan-2-Yl}-4-Phenylbutanamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303