3SKE: I. Novel Hcv Ns5b Polymerase Inhibitors: Discovery Of Indole 2- Carboxylic Acids With C3-Heterocycles

PDB ID: 3SKEDownload
MMDB ID: 93339
PDB Deposition Date: 2011/6/22
Updated in MMDB: 2012/09
Experimental Method:
x-ray diffraction
Resolution: 1.97  Å
Source Organism:
Similar Structures:
Biological Unit for 3SKE: monomeric; determined by software (PISA)
Molecular Components in 3SKE
Label Count Molecule
Protein (1 molecule)
1
HCV Ns5b RNA_dependent RNA Polymerase
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
Phosphate IonPhosphate Ion
2
1
1-[(2-Aminopyridin-4-Yl)methyl]-3-(2,4-Dioxo-1,2-Dihydrothieno[3,4-D]pyrimidin-3(4h)-Yl)-5-(Trifluoromethyl)-1h-Indole-2-Carboxylic Acid1-[(2-Aminopyridin-4-Yl)methyl]-3-(2,4-Dioxo-1,2-Dihydrothieno[3,4-D]pyrimidin-3(4h)-Yl)-5-(Trifluoromethyl)-1h-Indole-2-Carboxylic Acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303