3SHZ: Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors

PDB ID: 3SHZDownload
MMDB ID: 92954
PDB Deposition Date: 2011/6/17
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 2.449  Å
Source Organism:
Similar Structures:
Biological Unit for 3SHZ: monomeric; determined by author and by software (PISA)
Molecular Components in 3SHZ
Label Count Molecule
Protein (1 molecule)
1
Cgmp-specific 3',5'-cyclic Phosphodiesterase
(Gene symbol: PDE5A)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
1
5-chloro-6-ethyl-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one5-chloro-6-ethyl-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one
2
1
ZINC IONZINC ION
3
5
MAGNESIUM IONMAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303