3SFX: Cryptococcus neoformans protein farnesyltransferase in complex with FPT-II and tipifarnib

PDB ID: 3SFXDownload
MMDB ID: 92383
PDB Deposition Date: 2011/6/14
Updated in MMDB: 2011/10
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 3SFX: dimeric; determined by author and by software (PISA)
Molecular Components in 3SFX
Label Count Molecule
Proteins (2 molecules)
1
Cryptococcus Neoformans Protein Farnesyltransferase Alpha Subunit
Molecule annotation
1
Cryptococcus Neoformans Protein Farnesyltransferase Beta Subunit
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
1
ZINC IONZINC ION
2
3
(2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid(2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid
3
1
[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID
4
1
6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE
5
1
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303