3SAN: Crystal Structure Of Influenza A Virus Neuraminidase N5 Complexed With Zanamivir

Citation:
Abstract
There are 9 serotypes of neuraminidase (NA) from influenza A virus (N1 to N9), which are classified into two groups based on primary sequences (groups 1 and 2). The structural hallmark of the two groups is the presence or absence of an extra 150-cavity (formed by the 150-loop) in the active site. Thus far, structures of NAs from 6 out of the 9 serotypes have been solved. Here, we solved the N5 structure, the last unknown structure group 1 serotype with a unique Asn147 residue in its 150-loop, demonstrating that it has an extended 150-cavity that closes upon inhibitor binding.
PDB ID: 3SANDownload
MMDB ID: 92606
PDB Deposition Date: 2011/6/3
Updated in MMDB: 2011/08
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 3SAN: tetrameric; determined by author and by software (PISA)
Molecular Components in 3SAN
Label Count Molecule
Proteins (4 molecules)
4
Neuraminidase
Molecule annotation
Chemicals (28 molecules)
1
4
2
12
3
4
4
8
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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