National Center for
3S2O: Fragment Based Discovery and Optimisation of Bace-1 Inhibitors
Bioorg. Med. Chem. Lett. (2010) 20 p.5329-5333
A novel series of 2-aminobenzimidazole inhibitors of BACE1 has been discovered using fragment-based drug discovery (FBDD) techniques. The rapid optimization of these inhibitors using structure-guided medicinal chemistry is discussed.