3S2O: Fragment Based Discovery And Optimisation Of Bace-1 Inhibitors

Citation:
Abstract
A novel series of 2-aminobenzimidazole inhibitors of BACE1 has been discovered using fragment-based drug discovery (FBDD) techniques. The rapid optimization of these inhibitors using structure-guided medicinal chemistry is discussed.
PDB ID: 3S2ODownload
MMDB ID: 91051
PDB Deposition Date: 2011/5/17
Updated in MMDB: 2011/09
Experimental Method:
x-ray diffraction
Resolution: 2.6  Å
Source Organism:
Similar Structures:
Biological Unit for 3S2O: monomeric; determined by author and by software (PISA)
Molecular Components in 3S2O
Label Count Molecule
Protein (1 molecule)
1
Beta-secretase 1(Gene symbol: BACE1)
Molecule annotation
Chemicals (3 molecules)
1
1
2
2
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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