3S1Y: Amp-c Beta-lactamase (pseudomonas Aeruginosa) In Complex With A Beta- Lactamase Inhibitor

Citation:
Abstract
The bridged monobactam beta-lactamase inhibitor MK-8712 (1) effectively inhibits class C beta-lactamases. Side chain N-alkylated and ring-opened analogs of 1 were prepared and evaluated for combination with imipenem to overcome class C beta-lactamase mediated resistance. Although some analogs were more potent inhibitors of AmpC, none exhibited better synergy with imipenem than 1.
PDB ID: 3S1YDownload
MMDB ID: 91995
PDB Deposition Date: 2011/5/16
Updated in MMDB: 2011/07
Experimental Method:
x-ray diffraction
Resolution: 1.4  Å
Source Organism:
Similar Structures:
Biological Unit for 3S1Y: monomeric; determined by author and by software (PISA)
Molecular Components in 3S1Y
Label Count Molecule
Protein (1 molecule)
1
Beta-lactamase(Gene symbol: ampC)
Molecule annotation
Chemicals (4 molecules)
1
1
2
1
3
2
* Click molecule labels to explore molecular sequence information.

Citing MMDB
.