3RLJ: Crystal Structure Of The Androgen Receptor Ligand Binding Domain In Complex With Sarm S-22

Several new androgen receptor antagonists were synthesized and found to have varying activities across typically anti-androgen resistant mutants (Thr877 --> Ala and Trp741 --> Leu) and markedly improved potency over previously reported pan-antagonists. X-ray crystallography of a new anti-androgen in an androgen receptor mutant (Thr877 --> Ala) shows that the receptor can accommodate the added bulk presented by phenyl to naphthyl substitution, casting doubt on previous reports of predicted binding orientation and the causes of antagonism in bulky-B-ring antagonists.
PDB ID: 3RLJDownload
MMDB ID: 90361
PDB Deposition Date: 2011/4/19
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 3RLJ: monomeric; determined by author and by software (PISA)
Molecular Components in 3RLJ
Label Count Molecule
Protein (1 molecule)
Androgen Receptor(Gene symbol: AR)
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

Citing MMDB