3RL2: Hiv Nef Derived Peptide Nef73 Complexed To Hla-A0301

Human leukocyte antigens (HLA) are initially classified by serotyping but recently can be re-grouped by their peptide-presentation characteristics into supertypes. Both HLA-A*0301 and HLA-A*1101 are grouped into A3 supertype. Although a number of cross-presented T cell epitopes of HLA-A*0301 and HLA-A*1101 have been identified, the molecular mechanisms of cross-presentation remain elusive. Herein, the structures of HLA-A*0301 with two HIV-derived immunodominant T cell epitopes were solved and their characteristics in comparison with HLA-A*1101 presenting the same peptides were analyzed. The comparable structures of HLA-A*0301 and HLA-A*1101 with subtle differences illustrate the common modes of cross-presented peptides and the strict HLA-restriction of T cell receptor (TCR)-recognition.
PDB ID: 3RL2Download
MMDB ID: 97587
PDB Deposition Date: 2011/4/19
Updated in MMDB: 2012/03
Experimental Method:
x-ray diffraction
Resolution: 2.39  Å
Source Organism:
Human immunodeficiency virus 1
Similar Structures:
Biological Unit for 3RL2: trimeric; determined by author and by software (PISA)
Molecular Components in 3RL2
Label Count Molecule
Proteins (3 molecules)
HLA Class I Histocompatibility Antigen, A-3 Alpha Chain(Gene symbol: HLA-A)
Molecule annotation
Beta-2-microglobulin(Gene symbol: B2M)
Molecule annotation
Nef73 Peptide From Protein NEF
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB