3R22: Design, synthesis, and biological evaluation of pyrazolopyridine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (Part I)

PDB ID: 3R22Download
MMDB ID: 92550
PDB Deposition Date: 2011/3/11
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 2.9  Å
Source Organism:
Similar Structures:
Biological Unit for 3R22: monomeric; determined by author and by software (PISA)
Molecular Components in 3R22
Label Count Molecule
Protein (1 molecule)
1
Serine/threonine-protein Kinase 6
(Gene symbol: AURKA)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N-{5-[(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]pyridin-2-yl}methanesulfonamideN-{5-[(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]pyridin-2-yl}methanesulfonamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303