3QKM: Spirocyclic sulfonamides as AKT inhibitors

PDB ID: 3QKMDownload
MMDB ID: 89731
PDB Deposition Date: 2011/2/1
Updated in MMDB: 2024/11
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 3QKM: monomeric; determined by author and by software (PISA)
Molecular Components in 3QKM
Label Count Molecule
Protein (1 molecule)
1
Rac-alpha Serine/threonine-protein Kinase
(Gene symbol: AKT1)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N-(2-ethoxyethyl)-N-{(2S)-2-hydroxy-3-[(5R)-2-(quinazolin-4-yl)-2,7-diazaspiro[4.5]dec-7-yl]propyl}-2,6-dimethylbenzenesulfonamideN-(2-ethoxyethyl)-N-{(2S)-2-hydroxy-3-[(5R)-2-(quinazolin-4-yl)-2,7-diazaspiro[4.5]dec-7-yl]propyl}-2,6-dimethylbenzenesulfonamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303