3QKL: Spirochromane Akt Inhibitors

A novel series of spirochromane pan-Akt inhibitors is reported. SAR optimization furnished compounds with improved enzyme potencies and excellent selectivity over the related AGC kinase PKA. Attempted replacement of the phenol hinge binder provided compounds with excellent Akt enzyme and cell activities but greatly diminished selectivity over PKA.
PDB ID: 3QKLDownload
MMDB ID: 89563
PDB Deposition Date: 2011/2/1
Updated in MMDB: 2011/05
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
synthetic construct
Similar Structures:
Biological Unit for 3QKL: dimeric; determined by author and by software (PISA)
Molecular Components in 3QKL
Label Count Molecule
Proteins (2 molecules)
Rac-alpha Serine/threonine-protein Kinase(Gene symbol: AKT1)
Molecule annotation
Gsk-3 Beta Peptide
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

Citing MMDB