3QKK: Spirochromane Akt Inhibitors

PDB ID: 3QKKDownload
MMDB ID: 89562
PDB Deposition Date: 2011/2/1
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 3QKK: dimeric; determined by author and by software (PISA)
Molecular Components in 3QKK
Label Count Molecule
Proteins (2 molecules)
1
Rac-alpha Serine/threonine-protein Kinase
(Gene symbol: AKT1)
Molecule annotation
1
Glycogen Synthase Kinase-3 Beta
(Gene symbol: GSK3B)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N-(2-ethoxyethyl)-N-{(2S)-2-hydroxy-3-[(2R)-6-hydroxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,3'-piperidin]-1'-yl]propyl}-2,6-dimethylbenzenesulfonamideN-(2-ethoxyethyl)-N-{(2S)-2-hydroxy-3-[(2R)-6-hydroxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,3'-piperidin]-1'-yl]propyl}-2,6-dimethylbenzenesulfonamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303