3PX9: RTA in complex with N-(furanylmethyl)-7-carbamoyl-pterin

Citation:
Abstract
Ricin is a potent toxin found in castor seeds. The A chain, RTA, enzymaticlly depurinates a specific adenosine in ribosomal RNA, inhibiting protein synthesis. Ricin is a known chemical weapons threat having no effective antidote. This makes the discovery of new inhibitors of great importance. We have previously used 6-substituted pterins, such as pteroic acid, as an inhibitor platform with moderate success. We now report the success of 7-carboxy pterin (7CP) as an RTA inhibitor; its binding has been monitored using both kinetic and temperature shift assays and by X-ray crystallography. We also discuss the synthesis of various derivatives of 7CP, and their binding affinity and inhibitory effects, as part of a program to make effective RTA inhibitors.
PDB ID: 3PX9Download
MMDB ID: 91854
PDB Deposition Date: 2010/12/9
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 1.89  Å
Source Organism:
Similar Structures:
Biological Unit for 3PX9: monomeric; determined by author and by software (PISA)
Molecular Components in 3PX9
Label Count Molecule
Protein (1 molecule)
1
Preproricin
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

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