3PDJ: Crystal Structure Of Human 11-Beta-Hydroxysteroid Dehydrogenase 1 (11b-Hsd1) In Complex With 4,4-Disubstituted Cyclohexylbenzamide Inhibitor

Citation:
Abstract
The synthesis and SAR of a series of 4,4-disubstituted cyclohexylbenzamide inhibitors of 11beta-HSD1 are described. Optimization rapidly led to potent, highly selective, and orally bioavailable inhibitors demonstrating efficacy in both rat and non-human primate ex vivo pharmacodynamic models.
PDB ID: 3PDJDownload
MMDB ID: 94023
PDB Deposition Date: 2010/10/22
Updated in MMDB: 2011/10
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 3PDJ: dimeric; determined by author and by software (PISA)
Molecular Components in 3PDJ
Label Count Molecule
Proteins (2 molecules)
2
Corticosteroid 11-beta-dehydrogenase Isozyme 1(Gene symbol: HSD11B1)
Molecule annotation
Chemicals (4 molecules)
1
2
2
2
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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