3P70: Structural basis of thrombin-mediated factor V activation: essential role of the hirudin-like sequence Glu666-Glu672 for processing at the heavy chain-B domain junction

PDB ID: 3P70Download
MMDB ID: 93874
PDB Deposition Date: 2010/10/11
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.55  Å
Source Organism:
Similar Structures:
Biological Unit for 3P70: trimeric; determined by author and by software (PISA)
Molecular Components in 3P70
Label Count Molecule
Proteins (3 molecules)
1
Human Alpha-thrombin, Light Chain
(Gene symbol: F2)
Molecule annotation
1
Human Alpha-thrombin, Heavy Chain
(Gene symbol: F2)
Molecule annotation
1
Human Factor V, A2-b Domain Linker
(Gene symbol: F5)
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
5
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
1
BENZAMIDINEBENZAMIDINE
3
2
SODIUM IONSODIUM ION
4
1
beta-D-glucopyranosebeta-D-glucopyranose
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303