3P5O: Crystal Structure of the First Bromodomain of Human Brd4 in complex with IBET inhibitor

PDB ID: 3P5ODownload
MMDB ID: 86336
PDB Deposition Date: 2010/10/9
Updated in MMDB: 2010/12
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 3P5O: monomeric; determined by author and by software (PISA)
Molecular Components in 3P5O
Label Count Molecule
Protein (1 molecule)
1
Bromodomain-containing Protein 4
(Gene symbol: BRD4)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide
2
4
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303