National Center for
3P3H: Human Carbonic Anhydrase Ii In Complex With P-(5-ferrocenyl-1h-1,2,3- Triazol-1-yl)benzenesulfonamide
Chem. Commun. (Camb. ) (2012) 48 p.2328-2330
We have determined the protein X-ray crystal structures of four organometallic inhibitors in complex with their target enzyme carbonic anhydrase II. The barrel-shaped hydrophobic ferrocene and ruthenocene moieties have provided a structure-based avenue to better occupy the hydrophobic binding patch within the enzyme active site.