3OUJ: PHD2 with 2-Oxoglutarate

Citation:
Abstract
HIF prolyl 4-hydroxylases (PHD) are a family of enzymes that mediate key physiological responses to hypoxia by modulating the levels of hypoxia inducible factor 1-alpha (HIF1alpha). Certain benzimidazole-2-pyrazole carboxylates were discovered to be PHD2 inhibitors using ligand- and structure-based methods and found to be potent, orally efficacious stimulators of erythropoietin secretion in vivo.
PDB ID: 3OUJDownload
MMDB ID: 86650
PDB Deposition Date: 2010/9/14
Updated in MMDB: 2010/12
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 3OUJ: monomeric; determined by author and by software (PISA)
Molecular Components in 3OUJ
Label Count Molecule
Protein (1 molecule)
1
EGL Nine Homolog 1(Gene symbol: EGLN1)
Molecule annotation
Chemicals (3 molecules)
1
1
2
1
3
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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