3ORE: Crystal Structure Of Ttha0988 In Space Group P6522

The Thermus thermophilus protein TTHA0988 is a protein of unknown function which represents a fusion of two proteins found almost ubiquitously across the bacterial kingdom. These two proteins perform a role regulating sporulation in Bacillus subtilis, where they are known as KipI and KipA. kipI and kipA genes are usually found immediately adjacent to each other and are often fused to produce a single polypeptide, as is the case with TTHA0988. Here, three crystal forms are reported of TTHA0988, the first structure to be solved from the family of `KipI-KipA fusion' proteins. Comparison of the three forms reveals structural flexibility which can be described as a hinge motion between the `KipI' and `KipA' components. TTHA0988 is annotated in various databases as a putative allophanate hydrolase. However, no such activity could be identified and genetic analysis across species with known allophanate hydrolases indicates that a misannotation has occurred.
PDB ID: 3OREDownload
MMDB ID: 88361
PDB Deposition Date: 2010/9/7
Updated in MMDB: 2011/05
Experimental Method:
x-ray diffraction
Resolution: 2.9  Å
Source Organism:
Similar Structures:
Biological Unit for 3ORE: monomeric; determined by author and by software (PISA)
Molecular Components in 3ORE
Label Count Molecule
Protein (1 molecule)
Putative Uncharacterized Protein Ttha0988
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB