3OG4: The Crystal Structure Of Human Interferon Lambda 1 Complexed With Its High Affinity Receptor In Space Group P21212

Citation:
Abstract
Interferon (IFN)-lambda1 [also known as interleukin (IL)-29] belongs to the recently discovered group of type III IFNs. All type III IFNs initiate signaling processes through formation of specific heterodimeric receptor complexes consisting of IFN-lambdaR1 and IL-10R2. We have determined the structure of human IFN-lambda1 complexed with human IFN-lambdaR1, a receptor unique to type III IFNs. The overall structure of IFN-lambda1 is topologically similar to the structure of IL-10 and other members of the IL-10 family of cytokines. IFN-lambdaR1 consists of two distinct domains having fibronectin type III topology. The ligand-receptor interface includes helix A, loop AB, and helix F on the IFN site, as well as loops primarily from the N-terminal domain and inter-domain hinge region of IFN-lambdaR1. Composition and architecture of the interface that includes only a few direct hydrogen bonds support an idea that long-range ionic interactions between ligand and receptor govern the process of initial recognition of the molecules while hydrophobic interactions finalize it.
PDB ID: 3OG4Download
MMDB ID: 85636
PDB Deposition Date: 2010/8/16
Updated in MMDB: 2010/10
Experimental Method:
x-ray diffraction
Resolution: 2.16  Å
Source Organism:
Similar Structures:
Biological Unit for 3OG4: dimeric; determined by author and by software (PISA)
Molecular Components in 3OG4
Label Count Molecule
Proteins (2 molecules)
1
Interleukin-29(Gene symbol: IFNL1)
Molecule annotation
1
Interleukin 28 Receptor, Alpha (Interferon, Lambda Receptor)
Molecule annotation
Chemicals (4 molecules)
1
3
2
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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