3O8Y: Stable-5-Lipoxygenase

The synthesis of both proinflammatory leukotrienes and anti-inflammatory lipoxins requires the enzyme 5-lipoxygenase (5-LOX). 5-LOX activity is short-lived, apparently in part because of an intrinsic instability of the enzyme. We identified a 5-LOX-specific destabilizing sequence that is involved in orienting the carboxyl terminus, which binds the catalytic iron. Here, we report the crystal structure at 2.4 angstrom resolution of human 5-LOX stabilized by replacement of this sequence.
PDB ID: 3O8YDownload
MMDB ID: 88066
PDB Deposition Date: 2010/8/3
Updated in MMDB: 2018/07
Experimental Method:
x-ray diffraction
Resolution: 2.389  Å
Source Organism:
Similar Structures:
Biological Unit for 3O8Y: monomeric; determined by author and by software (PISA)
Molecular Components in 3O8Y
Label Count Molecule
Protein (1 molecule)
Arachidonate 5-lipoxygenase(Gene symbol: ALOX5)
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

Citing MMDB