National Center for
3O6G: Ligand-binding Domain Of Glua2 (flip) Ionotropic Glutamate Receptor In Complex With An Allosteric Modulator
Bioorg. Med. Chem. Lett. (2010) 20 p.6072-6075
Starting from lead compound 1, we demonstrate how X-ray structural data can be used to understand SAR and expediently optimize bioavailability in a novel series of AMPA receptor modulators, furnishing 5 with improved bioavailability and robust in vivo activity.