3O6G: Ligand-binding Domain Of Glua2 (flip) Ionotropic Glutamate Receptor In Complex With An Allosteric Modulator

Citation:
Abstract
Starting from lead compound 1, we demonstrate how X-ray structural data can be used to understand SAR and expediently optimize bioavailability in a novel series of AMPA receptor modulators, furnishing 5 with improved bioavailability and robust in vivo activity.
PDB ID: 3O6GDownload
MMDB ID: 84889
PDB Deposition Date: 2010/7/29
Updated in MMDB: 2010/12
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Similar Structures:
Biological Unit for 3O6G: dimeric; determined by author
Molecular Components in 3O6G
Label Count Molecule
Proteins (2 molecules)
2
Glutamate Receptor 2(Gene symbol: Gria2)
Molecule annotation
Chemicals (17 molecules)
1
2
2
6
3
1
4
8
* Click molecule labels to explore molecular sequence information.

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