3O5N: Tetrahydroquinoline carboxylates are potent inhibitors of the Shank PDZ domain, a putative target in autism disorders

PDB ID: 3O5NDownload
MMDB ID: 91828
PDB Deposition Date: 2010/7/28
Updated in MMDB: 2011/08
Experimental Method:
x-ray diffraction
Resolution: 1.83  Å
Source Organism:
Similar Structures:
Molecular Components in 3O5N
Label Count Molecule
Proteins (8 molecules)
8
SH3 and Multiple Ankyrin Repeat Domains Protein 3
(Gene symbol: Shank3)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(3aS,4R,9bR)-9-nitro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4,6-dicarboxylic acid(3aS,4R,9bR)-9-nitro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4,6-dicarboxylic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303