3O3Z: Complex of a chimeric alpha/beta-peptide based on the gp41 CHR domain bound to a gp41 NHR domain peptide

Citation:
Abstract
Infection of cells by HIV depends upon profound structural rearrangements within the trimeric viral protein gp41. Critical to this process is the formation of a six-helix bundle in which a set of three N-terminal heptad repeat (NHR) helices assemble to form a core displaying long grooves that provide docking sites for three C-terminal heptad repeat (CHR) helices. We report experiments designed to discriminate between two alternative hypotheses regarding the source of affinity between individual CHR helices and the complementary groove: (1) affinity is dominated by interactions of a small cluster of side chains at one end of the CHR helix; or (2) affinity depends upon interactions distributed across the long CHR helix. We have employed two complementary experimental designs, and results from both favor the latter hypothesis.
PDB ID: 3O3ZDownload
MMDB ID: 164128
PDB Deposition Date: 2010/7/26
Updated in MMDB: 2018/07
Experimental Method:
x-ray diffraction
Resolution: 2.6  Å
Similar Structures:
Biological Unit for 3O3Z: hexameric; determined by author and by software (PISA)
Molecular Components in 3O3Z
Label Count Molecule
Proteins (6 molecules)
3
Envelope Glycoprotein Gp160
Molecule annotation
3
Chimeric Alpha/beta Peptide Based on Gp41 CHR Domain Sequence
Molecule annotation
Chemicals (6 molecules)
1
6
* Click molecule labels to explore molecular sequence information.

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