3NS7: Succinic Acid Amides as P2-P3 Replacements for Inhibitors of Interleukin-1beta Converting Enzyme (ICE or Caspase 1)

PDB ID: 3NS7Download
MMDB ID: 92708
PDB Deposition Date: 2010/7/1
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.6  Å
Source Organism:
Similar Structures:
Biological Unit for 3NS7: dimeric; determined by author and by software (PISA)
Molecular Components in 3NS7
Label Count Molecule
Proteins (2 molecules)
1
Caspase-1
(Gene symbol: CASP1)
Molecule annotation
1
Caspase-1
(Gene symbol: CASP1)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(3S)-4-hydroxy-3-{[(2S)-4-{[2-(2-methyl-1H-benzimidazol-1-yl)ethyl]amino}-2-(1-methylethyl)-4-oxobutanoyl]amino}butanoic acid(3S)-4-hydroxy-3-{[(2S)-4-{[2-(2-methyl-1H-benzimidazol-1-yl)ethyl]amino}-2-(1-methylethyl)-4-oxobutanoyl]amino}butanoic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303