3NFA: Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design

PDB ID: 3NFADownload
MMDB ID: 90149
PDB Deposition Date: 2010/6/10
Updated in MMDB: 2012/05
Experimental Method:
x-ray diffraction
Resolution: 1.95  Å
Source Organism:
Similar Structures:
Biological Unit for 3NFA: dimeric; determined by author and by software (PISA)
Molecular Components in 3NFA
Label Count Molecule
Proteins (2 molecules)
2
Integrase
Molecule annotation
Chemicals and Non-standard biopolymers (17 molecules)
1
8
SULFATE IONSULFATE ION
2
4
6-[(5-bromo-2,3-dioxo-2,3-dihydro-1H-indol-1-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxylic acid6-[(5-bromo-2,3-dioxo-2,3-dihydro-1H-indol-1-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxylic acid
3
5
ACETIC ACIDACETIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303