3NCM: NEURAL CELL ADHESION MOLECULE, MODULE 2, NMR, 20 STRUCTURES

Citation:
Abstract
The structure in solution of the second Ig-module fragment of residues 117-208 of NCAM has been determined. Like the first Ig-module of residues 20-116, it belongs to the I set of the immunogloblin superfamily. Module 1 and module 2 interact weakly, and the binding sites of this interaction have been identified. The two-module fragment NCAM(20-208) is a stable dimer. Removal of the charged residues in these sites in NCAM(20-208) abolishes the dimerization. Modeling the dimer of NCAM(20-208) to fit the interactions of these charges produces one coherent binding site for the formation of two antiparallel strands of the first two NCAM modules. This mode of binding could be a major element in trans-cellular interactions in neural cell adhesion.
PDB ID: 3NCMDownload
MMDB ID: 11038
PDB Deposition Date: 1998/9/21
Updated in MMDB: 2017/12
Experimental Method:
solution nmr
Source Organism:
Similar Structures:
Biological Unit for 3NCM: monomeric; determined by author
Molecular Components in 3NCM
Label Count Molecule
Protein (1 molecule)
1
Protein (Neural Cell Adhesion Molecule, Large Isoform)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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