3LXK: Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6

PDB ID: 3LXKDownload
MMDB ID: 82488
PDB Deposition Date: 2010/2/25
Updated in MMDB: 2021/10
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 3LXK: monomeric; determined by author and by software (PISA)
Molecular Components in 3LXK
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase Jak3
(Gene symbol: JAK3)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303