3LKF: Leukocidin F (Hlgb) From Staphylococcus Aureus With Phosphocholine Bound

Staphylococcal LukF, LukS, HgammaII, and alpha-hemolysin are self-assembling, channel-forming proteins related in sequence and function. In the alpha-hemolysin heptamer, the channel-forming beta-strands and the amino latch make long excursions from the protomer core. Here we report the crystal structure of the water soluble form of LukF. In the LukF structure the channel-forming region folds into an amphipathic, three-strand beta-sheet and the amino latch forms a beta-strand extending a central beta-sheet. The LukF structure illustrates how a channel-forming toxin masks protein-protein and protein-membrane interfaces prior to cell binding and assembly, and together with the alpha-hemolysin heptamer structure, they define the end points on the pathway of toxin assembly.
PDB ID: 3LKFDownload
MMDB ID: 11034
PDB Deposition Date: 1998/7/28
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 3LKF: monomeric; determined by author
Molecular Components in 3LKF
Label Count Molecule
Protein (1 molecule)
Leukocidin F Subunit
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

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