3LJ3: PI3-kinase-gamma with a pyrrolopyridine-benzofuran inhibitor

PDB ID: 3LJ3Download
MMDB ID: 81414
PDB Deposition Date: 2010/1/25
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 2.43  Å
Source Organism:
Similar Structures:
Biological Unit for 3LJ3: monomeric; determined by author
Molecular Components in 3LJ3
Label Count Molecule
Protein (1 molecule)
1
Phosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit Gamma Isoform
(Gene symbol: PIK3CG)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
2
SULFATE IONSULFATE ION
2
1
(2Z)-4,6-dihydroxy-2-{[1-methyl-4-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]methylidene}-1-benzofuran-3(2H)-one(2Z)-4,6-dihydroxy-2-{[1-methyl-4-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]methylidene}-1-benzofuran-3(2H)-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303