National Center for
3LAU: Crystal Structure of Aurora2 kinase in complex with a GSK3beta inhibitor
Bioorg. Med. Chem. Lett. (2010) 20 p.1985-1989
From an HTS hit, a series of potent and selective inhibitors of GSK3beta have been designed based on a Cdk2-homology model and with the help of several crystal structures of the compounds within Cdk2.