3L95: Crystal structure of the human Notch1 Negative Regulatory Region (NRR) bound to the fab fragment of an antagonist antibody

PDB ID: 3L95Download
MMDB ID: 80686
PDB Deposition Date: 2010/1/4
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 2.19  Å
Source Organism:
Similar Structures:
Biological Unit for 3L95: pentameric; determined by author and by software (PISA)
Molecular Components in 3L95
Label Count Molecule
Proteins (5 molecules)
1
Anti-nrr1 FAB Fragment Light Chain
Molecule annotation
2
Anti-nrr1 FAB Fragment Heavy Chain
Molecule annotation
2
Neurogenic Locus Notch Homolog Protein 1
(Gene symbol: NOTCH1)
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
2
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
1
SULFATE IONSULFATE ION
3
6
CALCIUM IONCALCIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303