3KVM: Crystal structure of human dihydroorotate dehydrogenase (DHODH) with amino-benzoic acid inhibitor 951 at 2.00A resolution

Citation:
Abstract
Amino-benzoic acid derivatives 1-4 were found to be inhibitors for DHODH by virtual screening, biochemical, and X-ray crystallographic studies. X-ray structures showed that 1 and 2 bind to DHODH as predicted by virtual screening, but 3 and 4 were found to be structurally different from the corresponding compounds initially identified by virtual screening.
PDB ID: 3KVMDownload
MMDB ID: 80496
PDB Deposition Date: 2009/11/30
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 3KVM: monomeric; determined by author and by software (PISA)
Molecular Components in 3KVM
Label Count Molecule
Protein (1 molecule)
1
Dihydroorotate Dehydrogenase, Mitochondrial(Gene symbol: DHODH)
Molecule annotation
Chemicals (6 molecules)
1
1
2
1
3
1
4
1
5
1
6
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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